Dimethyl Sulfoxide
Apexbio Technology LLC Darapladib(Synonyms: SB-480848, Darapladib, LP-PLA2 inhibitor, SB480848), 10mM (in 1mL DMSO), CAS: A3349.
Darapladib (CAS 356057-34-6) is a selective inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) an enzyme strongly implicated in the progression and instability of atherosclerotic plaques In vitro Darapladib shows high potency toward Lp-PLA2 (IC50 approximately 270 pM) with minimal inhibition of other secretory PLA2 isoforms (e g III V X) Preclinical studies in ApoE-deficient mouse models demonstrate that inhibition of Lp-PLA2 attenuates vascular inflammatory processes and markedly reduces atherosclerotic lesion formation Clinically Darapladib administration in statin-treated patients significantly decreases plasma Lp-PLA2 activity and inflammatory markers indicating potential applications in cardiovascular research related to atherosclerosis and associated inflammation
Apexbio Technology LLC Pexidartinib (PLX3397) 1029044-16-3 10mM (in 1mL DMSO)
Pexidartinib (PLX3397 CAS 1029044-16-3) is a small molecule inhibitor targeting colony-stimulating factor 1 receptor (CSF-1R) a receptor tyrosine kinase involved in macrophage recruitment and activation Through inhibition of CSF-1R activity this compound reduces macrophage infiltration and accumulation demonstrated by diminished macrophage levels in B16F10 melanoma models without affecting Gr-1 myeloid-derived suppressor cells In vivo studies using GL261 glioma models in C57 mice indicate decreased microglial infiltration upon oral dosing with PLX3397 Clinically combined treatment with Pexidartinib and paclitaxel is under evaluation in advanced solid tumors and breast cancer trials
Apexbio Technology LLC NU7441 (KU-57788) 503468-95-9 10mM (in 1mL DMSO)
NU7441 (KU-57788 CAS 503468-95-9) is a selective inhibitor targeting DNA-dependent protein kinase (DNA-PK) via competition with ATP exhibiting an IC50 of approximately 13 nM and a Ki of 0 65 nM It demonstrates high specificity showing minimal inhibition of related kinases ATM and ATR at concentrations up to 100 M and substantially weaker activity towards mTOR and PI3K (IC50 values of 1 7 and 5 M respectively) NU7441 sensitizes HeLa cells to etoposide enhancing cytotoxicity and augments tumor growth delay when co-administered in SW620 xenograft mouse models The molecule serves as a tool compound in DNA repair and oncology research
Apexbio Technology LLC Caspofungin(Synonyms: Cancidas, Caspofungin acetate, MK-0991, L-743872), 10mM (in 1mL DMSO), CAS: 162808-62-0.
Caspofungin (CAS 162808-62-0) is a small-molecule inhibitor of -1 3-glucan synthase an enzyme essential for the biosynthesis of -(1 3)-D-glucan a fundamental cell wall component in pathogenic fungi such as Candida albicans Caspofungin selectively inhibits -1 3-glucan synthase activity with a reported IC50 of approximately 0 6 nmol/L in membrane preparations of C albicans Caspofungin demonstrates potent antifungal activity against various Candida isolates including azole-resistant strains (MIC90 0 5 g/mL) and shows prolonged post-antifungal effects lasting 6 8 hours It is widely utilized in biomedical research involving fungal infections and antifungal therapeutics
Chem-Impex International, Inc. Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 1L
Dimethyl sulfoxide, 67-68-5, MFCD00002089, 1L
U.S. Pharmacopeia Dimethyl Sulfoxide, 67-68-5, MFCD00002089, 3g
Molecular formula C2H6OS, Molecular weight 78.13, Melting Point 64.4 - 66.2 °F (18 - 19 °C), Boiling Point 372.2 °F (189 °C), Synonyms: DMSO, Methyl sulfoxide
Apexbio Technology LLC AZD7762(Synonyms: AZD-7762, AZD 7762, 860352-01-8), 10mM (in 1mL DMSO), CAS: 860352-01-8.
AZD7762 (CAS No 860352-01-8) is an ATP-competitive inhibitor targeting the checkpoint kinases Chk1 and Chk2 regulatory enzymes activated upon DNA damage that control cell-cycle progression through phosphorylation of CDC25 phosphatases By competitively binding the ATP-binding pocket of Chk1 AZD7762 blocks Chk1-mediated phosphorylation of CDC25C exhibiting an IC50 of approximately 5 nM and Ki of 3 6 nM This inhibition prevents DNA damage-induced cell cycle arrest and interrupts DNA repair mechanisms promoting apoptosis in tumor cells Consequently AZD7762 acts as a chemosensitizing agent enhancing the cytotoxic effects of DNA-damaging therapies in oncology research
Apexbio Technology LLC URB597(Synonyms: URB-597, KDS-4103, FAAH inhibitor URB597, Cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester), 10mM (in 1mL DMSO), CAS: 546141-08-6.
URB597 (CAS 546141-08-6) also known as KDS-4103 is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH) an enzyme responsible for intracellular hydrolysis of the endocannabinoid anandamide In vitro assays indicate that URB597 inhibits FAAH activity with IC values of 3 nM in human liver microsomes and 52 nM in rat brain membranes Intraperitoneal administration in rats results in FAAH inhibition within brain tissue (ID 0 15 mg/kg) URB597 exhibits minimal interaction with cannabinoid receptors anandamide transporters or other related receptors ion channels enzymes and transporters This selectivity makes URB597 valuable for investigating endocannabinoid signaling pathways in biomedical research
Apexbio Technology LLC Fenretinide 65646-68-6 10mM (in 1mL DMSO)
Fenretinide (4-HPR) is a synthetic retinoic acid analog which acts primarily through inhibition of focal adhesion kinase (FAK) and modulation of related signaling cascades Fenretinide induces apoptosis in various tumor cell lines such as prostate ovarian cervical endometrial breast small-cell lung carcinoma and malignant hematopoietic cells Mechanistically Fenretinide promotes apoptotic cell death through reactive oxygen species (ROS)-mediated DNA fragmentation and disrupts tumor cell migration and invasion via interference with the FAK/AKT/GSK3 signaling axis and destabilization of -catenin Fenretinide is frequently utilized as a chemopreventive agent in oncology research particularly for investigating mechanisms of growth inhibition and cell migration suppression
Apexbio Technology LLC Triapine 236392-56-6; 200933-27-3; 143621-35-6 10mM (in 1mL DMSO)
Triapine is a small molecule thiosemicarbazone derivative known to inhibit ribonucleotide reductase an enzyme essential for the conversion of ribonucleotides to deoxyribonucleotides thereby interfering with DNA synthesis and repair pathways Through this inhibition mechanism Triapine exhibits antitumor activity in a range of experimental cancer models including human ovarian carcinoma xenografts and murine leukemia models and inhibits proliferation across multiple tumor cell lines Due to its mechanistic specificity Triapine serves as a useful chemical tool for biomedical research into nucleic acid metabolism cancer cell replication and therapeutic resistance mechanisms
Supply Solutions Dimethyl sulfoxide | 67-68-5 | 78.14 g/mol | 50ML
Dimethyl sulfoxide | 67-68-5 | 78.14 g/mol | 50ML
Apexbio Technology LLC Ro 3306 872573-93-8 10mM (in 1mL DMSO)
Ro 3306 (CAS 872573-93-8) is an ATP-competitive inhibitor targeting cyclin-dependent kinase 1 (CDK1) It selectively inhibits CDK1/cyclin B1 and CDK1/cyclin A complexes (Ki values of 35 nM and 110 nM respectively) thereby interfering with mitotic entry In DU145 cells Ro 3306 at 1 M diminishes BRCA1 localization at DNA double-strand breaks and suppresses RAD51 foci formation sensitizing these cells to DNA-damaging agents such as AZ12253801 Hence Ro 3306 is useful in studying cell cycle regulation DNA repair mechanisms and sensitization of cancer cells to targeted therapies
Apexbio Technology LLC Y-27632 dihydrochloride 129830-38-2 10mM (in 1mL DMSO)
Y-27632 dihydrochloride (CAS 129830-38-2) is a small-molecule inhibitor targeting ROCK kinases (Rho-associated protein kinases) specifically interacting with the catalytic domains of ROCK-1 and ROCK-2 It inhibits their kinase activity with an IC50 of approximately 140 nM By targeting ROCK signaling Y-27632 disrupts Rho-mediated formation of cellular stress fibers influences cell cycle progression from G1 to S phase and interferes with cytokinesis It is commonly utilized in studies investigating cell proliferation cytoskeletal organization and stem cell viability
Apexbio Technology LLC Ferrostatin-1 (Fer-1) 347174-05-4 10mM (in 1mL DMSO)
Ferrostatin-1 (Fer-1) is a selective inhibitor of ferroptosis a regulated form of iron-dependent oxidative cell death characterized by lipid peroxidation It functions primarily by reducing lipid reactive oxygen species (ROS) thus inhibiting membrane lipid peroxidation and preventing ferroptosis induction triggered by compounds such as erastin In experimental contexts Fer-1 is employed to investigate ferroptotic pathways in different disease models including cancer biology neurodegeneration and ischemic injury Ferrostatin-1 demonstrates an IC50 value of approximately 60 nM in inhibiting ferroptosis induced by erastin in cellular assays rendering it suitable for mechanistic studies and therapeutic research involving modulation of iron-dependent oxidative damage pathways
Apexbio Technology LLC CYT387 1056634-68-4 10mM (in 1mL DMSO)
CYT387 (CAS 1056634-68-4) is an aminopyrimidine derivative identified through high-throughput screening and optimized with structure-guided medicinal chemistry It functions as an inhibitor targeting Janus kinase family enzymes JAK1 JAK2 JAK3 and TYK2 with reported IC50 values of 11 nM 18 nM 155 nM and 17 nM respectively At concentrations between 500 1500 nM CYT387 selectively suppresses JAK2 signaling inhibits proliferation of JAK2-dependent hematopoietic cell lines and induces apoptosis with minimal effects on non-hematopoietic cells CYT387 is employed in experimental studies of JAK2-mediated signaling pathways and myeloproliferative neoplasms