Dimethyl Sulfoxide
Apexbio Technology LLC Regorafenib 755037-03-7 10mM (in 1mL DMSO)
Regorafenib (CAS 755037-03-7) is an orally bioavailable inhibitor targeting multiple receptor tyrosine kinases (RTKs) such as VEGFR1/2/3 PDGFR Kit RET Raf-1 B-RAF and B-RAFV600E By impeding kinase phosphorylation (IC50 values ranging from approximately 1 5 46 nM) regorafenib disrupts signaling pathways associated with angiogenesis tumor cell proliferation and metastasis Preclinically regorafenib inhibited VEGFR2 phosphorylation (IC50 3 nM) and reduced VEGF-induced endothelial cell proliferation in vitro In rodent tumor xenograft models it demonstrated dose-dependent tumor growth suppression and antimetastatic potential supporting its utility for oncology research
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 | C2H6OS | 1mL
Dimethyl sulfoxide (Standard) is the analytical standard of Dimethyl sulfoxide This product is intended for research and analytical applications Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves both polar and nonpolar compounds Dimethyl sulfoxide has anti-freezing and bacteriostatic properties[1][2]
Apexbio Technology LLC LB42708 226929-39-1 10mM (in 1mL DMSO)
LB42708 (CAS 226929-39-1) is a selective small-molecule inhibitor of farnesyltransferase (FTase) belonging to a non-peptidic pyrrole-based class It blocks FTase-mediated farnesylation of H-Ras N-Ras and K-Ras4B demonstrated by low nanomolar IC50 values (0 8 nM 1 2 nM and 2 nM respectively) LB42708 shows minimal inhibitory effect on geranylgeranyltransferase I In vitro studies indicate inhibition of Ras-driven signaling pathways decreasing Ras activation and subsequently suppressing VEGF-stimulated endothelial proliferation and migration Researchers use LB42708 in oncology and inflammation studies exemplified by reduced tumor growth in Ras-mutant HCT116 and wild-type Caco-2 xenograft models
Apexbio Technology LLC Alexidine dihydrochloride 1715-30-6 10mM (in 1mL DMSO)
Alexidine dihydrochloride is a selective inhibitor targeting mitochondrial protein tyrosine phosphatase 1 (PTPMT1) exhibiting inhibitory activity with an IC50 value of approximately 1 08 M in vitro By inhibiting PTPMT1 Alexidine dihydrochloride modulates mitochondrial signaling pathways implicated in cellular metabolism Additionally this compound enhances insulin secretion in pancreatic -cells of rat islet models In cancer biology research Alexidine dihydrochloride demonstrates activity against FaDu cells providing a relevant tool for studying mitochondrial phosphatase-mediated mechanisms in oncology and diabetes-related research applications
Apexbio Technology LLC Chlorpromazine HCl 69-09-0 10mM (in 1mL DMSO)
Chlorpromazine HCl (CAS 69-09-0) is a phenothiazine-based dopamine receptor antagonist with significant activity at G protein-coupled dopamine receptors in the central nervous system Mechanistically chlorpromazine directly binds to dopamine receptors competitively inhibiting receptor-ligand interactions as evidenced by its inhibition of [ H]spiperone binding in vitro In vivo studies indicate chronic chlorpromazine administration in rats induces behavioral sensitization and altered motor responses linked to DA and NMDA receptor function Clinically chlorpromazine is established as a conventional antipsychotic approved for schizophrenia treatment making it valuable in neuropharmacology research
Apexbio Technology LLC LY364947 396129-53-6 10mM (in 1mL DMSO)
LY364947 (CAS 396129-53-6) is a selective inhibitor targeting the kinase domain of transforming growth factor- (TGF- ) type I receptor TGF- signaling regulates crucial biological processes such as cell proliferation differentiation and tissue homeostasis In vitro studies demonstrated that LY364947 inhibits the receptor kinase activity with an IC50 of 51 nM effectively suppressing TGF- -dependent luciferase activity in mink lung epithelial cells (p3TP Lux assay) and growth of NIH 3T3 fibroblasts In vivo LY364947 showed protective effects against NMDA-induced retinal degeneration in rats attenuating retinal ganglion cell loss and capillary degradation Thus LY364947 serves as a valuable pharmacological tool in TGF- -related research and associated pathological conditions
Apexbio Technology LLC Kinetin 525-79-1 10mM (in 1mL DMSO)
Kinetin (N6-furfuryladenine) is a natural adenine derivative classified as a cytokinin originating from plant tissues and participates in diverse physiological processes including cell division and cellular differentiation Structurally kinetin contains an adenine core with a furfuryl substituent at position N6 Experimentally kinetin induces apoptosis-like morphological changes nuclear fragmentation and hypoploidy in vitro in various cell types Additionally kinetin contributes to modulation of RNA splicing patterns notably demonstrated through the promotion of exon 20 inclusion in familial dysautonomia models Due to these properties kinetin serves as an investigational tool in studies of RNA processing apoptosis mechanisms and is examined as a potential therapeutic agent in splicing-associated diseases
Selleck Chemical LLC UBCS039, Solution 10mM (1mL in DMSO)
UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.
Selleck Chemical LLC OSS_128167, 10mM (1mL in DMSO)
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.
Medchemexpress LLC Dm4 Solution 10Mm1Ml In Dmso | HY-12454-10MM1ML/DMSO SOL
Dm4 Solution 10Mm1Ml In Dmso
eMolecules 2168-93-6 | n-Butyl sulfoxide | Oakwood Chemicals | MFCD00002093 | 162.290 | C8H18OS | 96.000 | CCCCS(=O)CCCC | 25g | 480102057
n-Butyl sulfoxide | Oakwood Chemicals | 2168-93-6 | MFCD00002093 | 162.290 | C8H18OS | 96.000 | CCCCS(=O)CCCC | 25g | 480102057
Medchemexpress LLC Dnl343 Solution 10Mm 1Ml Dmso | HY149555-10MM 1ML DMSO
Dnl343 Solution 10Mm 1Ml Dmso
Medchemexpress LLC Bay-9835 10Mm Dmso Reconst 1Ml | HY-162284-10MM-DMSO-RECON
Bay-9835 10Mm Dmso Reconst 1Ml
Apexbio Technology LLC AZD6244 (Selumetinib) 606143-52-6 10mM (in 1mL DMSO)
AZD6244 (Selumetinib CAS 606143-52-6) is a small-molecule inhibitor selectively targeting MEK1/2 components of the MAP kinase signaling cascade It inhibits MEK1 via a non-ATP-competitive mechanism with an IC50 of 14 1 nM leading to decreased phosphorylation of downstream targets ERK1/2 (IC50 10 3 nM cellular assays) AZD6244 exhibits minimal off-target activity against related kinases including MKK6 EGFR ErbB2 and B-Raf In tumor cell lines harboring activated Ras or B-Raf mutations AZD6244 reduces cell proliferation and inhibits growth in xenograft models Thus AZD6244 is useful for investigating MAP kinase pathway-driven malignancies